Author

Satoru Nagatoishi

Medical Device Development and Regulation Research CenterORCID 0000-0002-0794-3963Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Kouhei TsumotoiD· 2 shared Akinobu SenooiD· 1 shared Alexander TyshkovskiyiD· 1 shared Bohan ZhangiD· 1 shared C. Kim· 1 shared Chika SaegusaiD· 1 shared Chitose SuzukiiD· 1 shared Daisuke SaigusaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

Kouhei TsumotoORCID

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3 papers

Recent·Most cited

Structural basis for the intestinal protocadherin-based intermicrovillar adhesion complex

Akinobu Senoo, Pablo Adrian Guillen-Poza, Karin Fujishima, Hirofumi Kosuge, Takamasa Doumoto, Keisuke Kasahara, Tomohito Tanihara, Yuya Yoshida, Saeko Yanaka, Makoto Nakakido, Satoru Nagatoishi, Katsumi Maenaka, Shigehiro Ohdo, Naoya Matsunaga, Rubén Hervás, , José M. M. Caaveiro

The paper determines the Cryo-EM structure of the intestinal IMAC complex, revealing its heterotetrameric composition and structural features that enable microvilli adhesion and resilience to shear stress.

bioRxiv · May 14, 2026 · PreprintBiophysics

Non-DNA-damaging DNA-PK activation improving hearing and prolonging life due to NAD+ and SIRT upregulation

Yohei Honkura, Takehiro Suzuki, Ryota Kujirai, Shin-ichiro Kanno, Yotaro Matsumoto, Yoshikazu Tanaka, Kowit Hengphasatporn, Satoru Nagatoishi, Alexander Tyshkovskiy, Tomoko Kasahara, Yoshiyasu Tongu, Bohan Zhang, Hitomi Kashiwagi, Chika Saegusa, Msato Fujioka, , Takaaki Abe

This paper shows that MA-5 improves hearing loss and extends lifespan in mice by increasing NAD+ and SIRT1 through DNA-PK activation and mitochondrial function.

bioRxiv · Apr 18, 2025 · PreprintCell Biology

De novo chemo-optogenetics through rational small-molecule design and TRAP display

Tomoki Miyazaki, Tomoshige Fujino, Tatsuyuki Yoshii, Mamoru Funane, Naoya Murata, C. Kim, Satoru Nagatoishi, Kouhei Tsumoto, Gosuke Hayashi, Hiroshi Murakami, Shinya Tsukiji

This paper introduces a method to create synthetic chemo-optogenetic tools by combining rational small-molecule design with TRAP display to generate light-controlled protein binders.

bioRxiv · Apr 10, 2025 · PreprintSynthetic Biology