Paul Huang

Enhancement of a STING Agonist Vaccine for Tuberculosis Using Locally Supercharged MS2 Viral Capsids

This paper develops a vaccine platform using MS2 viral capsids to deliver an Mtb antigen and STING agonist, reducing the required dose and cost while maintaining efficacy.

Viral capsid delivery of cGAMP enhances STING-dependent antitumor immune response

This study shows that delivering cGAMP via bacteriophage MS2 nanoparticles enhances STING activation and antitumor immunity in mice.

Engineered MS2 Virus Capsids for Cellular Display of Peptide Antigens

This paper develops a viral capsid-based vaccine platform using MS2 virus to display peptide antigens, demonstrating effective T-cell activation and MHC presentation in vitro.

Cytosolic delivery of anionic cyclic dinucleotide STING agonists with locally supercharged viral capsids

This study develops a viral capsid-based delivery system for anionic CDN STING agonists, enhancing cell uptake and STING activation while avoiding toxicity.