Frédérique White

Epistasis and an oligogenic architecture underlie the strength of a plant-herbivore interaction

The paper examines how genomic variation in Arabidopsis thaliana affects interaction strength with aphids, finding epistasis among defense genes and an oligogenic architecture.

EpiATLAS - a reference for human epigenomic research

EpiATLAS provides a comprehensive collection of human reference epigenomes to advance epigenomic research and understanding of cellular function and disease.

Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects

The paper conducts a multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycemic traits, identifying novel loci and highlighting limited pregnancy-specific genetic effects.

Development of a microRNA clock for gestational age in the general population

This paper develops a miRNA-based gestational age clock (miRClock-GA) using cord blood plasma miRNA data and validates it in an independent cohort, showing associations with birthweight and childhood BMI.

Long-read transcriptome assembly reveals vast transcriptional complexity in the placenta associated with metabolic and endocrine function

The paper uses long-read RNA-seq to create a comprehensive placental transcriptome reference, revealing high transcriptional complexity and identifying novel isoforms associated with metabolic and endocrine functions in gestational diabetes.

Leveraging the largest harmonized epigenomic data collection for metadata prediction validated and augmented over 350,000 public epigenomic datasets

The paper develops EpiClass, a machine learning tool that predicts and corrects metadata for over 350,000 epigenomic datasets with high accuracy.

Maternal obesity and offspring neurodevelopment are associated with hypoxic gene expression in term human placenta

The paper links maternal obesity to hypoxia gene expression in term placenta and its association with offspring neurodevelopmental outcomes.

Genome-wide association study of placental weight in 179,025 children and parents reveals distinct and shared genetic influences between placental and fetal growth

This study identifies 40 genetic loci associated with placental weight using GWAS in 179,025 children and parents, revealing shared and distinct genetic influences with fetal growth.

Identification and application of plasmatic microRNA expression quantitative trait loci (miR-QTL) at first trimester of pregnancy

The paper identifies miRNA expression quantitative trait loci (miR-QTL) in pregnancy and links them to pregnancy complications using genetic risk scores.