Heng‐Ye Man

Subthreshold membrane depolarization powerfully engages intracellular calcium dynamics in the awake mammalian brain

The paper investigates how subthreshold membrane depolarization influences intracellular calcium dynamics in awake mice, showing strong coupling during prolonged depolarization and weaker coupling during isolated spikes.

Human-specific multicopy gene FRMPD2 promotes synapse formation via recruitment of neuroligin 1

This study identifies FRMPD2 as a human-specific gene that promotes synapse formation by recruiting neuroligin-1 and interacting with the F-actin network, with implications for brain development and cognitive function.

Reactivation of the X-linked Nexmif Gene Corrects Mosaic NEXMIF Deficiency in Heterozygous Female Mice

This study shows that reactivating the silenced X chromosome in heterozygous Nexmif-deficient mice improves neuronal and behavioral deficits using pharmacological and CRISPRa approaches.

Sexually dimorphic phenotypes and the role of androgen receptors in UBE3A-dependent autism spectrum disorder

This study investigates sex differences in UBE3A-dependent autism spectrum disorder using a mouse model, finding that androgen receptor dysregulation contributes to sexually dimorphic behavioral and molecular changes.

AutoMorFi: Automated Whole-image Morphometry in Fiji/ImageJ for Diverse Analyses and Discoveries

AutoMorFi automates whole-image morphometric analysis, generating over 47 measurements per cell quickly and enabling new discoveries across diverse biological samples.

The autism spectrum disorder risk gene NEXMIF alters hippocampal CA1 cellular and network dynamics

This study investigates how the ASD risk gene NEXMIF affects hippocampal CA1 network dynamics in mice, finding increased synchronization and exaggerated movement responses without changes in individual neuron excitability.

RTP801 REGULATES MOTOR CORTEX SYNAPTIC TRANSMISSION AND LEARNING

This study shows that RTP801 regulates synaptic transmission and motor learning by modulating synaptic plasticity in the motor cortex.

Large-scale voltage imaging in the brain using targeted illumination

This paper demonstrates targeted illumination with SomArchon to enable large-scale voltage imaging in the brain, improving signal contrast and reducing background contamination.

Neural Stimulation in vitro and in vivo by Photoacoustic Nanotransducers

This paper introduces photoacoustic nanotransducers for precise non-genetic neural stimulation in vitro and in vivo with high spatial and temporal resolution.

Optoacoustic brains stimulation at submillimeter spatial precision

This paper introduces a miniaturized Fiber-Optoacoustic Converter for high spatial precision neural stimulation in mice, achieving submillimeter resolution in vivo.