Michael MacLean

The paper examines how genetic and tissue-specific factors influence the neuroinflammatory response to LPS in different brain regions of mice.

Crop-OCT is an automated pipeline for analyzing OCT images to identify retinopathy in murine models, enabling the detection of regional and focal lesions across multiple diseases.

This study shows that IL1A enhances TNF-induced retinal ganglion cell death in a SARM1-dependent manner after combined insult.

The paper examines retinal vascular changes in Mthfr677C>T mice, finding similarities to cerebrovascular changes in AD, suggesting retinal assessment as a potential biomarker.

This study examines retinal aging across nine genetically diverse mouse strains, identifying molecular aging signatures and validating WSB and NZO as models for retinal neurodegenerative diseases.

This study shows that microglia depletion in aged mice increases optic nerve damage in glaucoma models, suggesting microglia protect against ocular hypertension-induced retinal ganglion cell loss.

This study shows that metabolic syndrome in NZO mice reduces microglial plasticity and increases vascular interactions compared to B6J mice.