Olivia J. Marola

Crop-OCT is an automated pipeline for analyzing OCT images to identify retinopathy in murine models, enabling the detection of regional and focal lesions across multiple diseases.

The paper develops a custom Cellpose script and models to automate RGC soma quantification and characterization in retinas.

This study shows MKK4 and MKK7 drive RGC soma and axon degeneration after glaucoma injury, while DDIT3/JUN only prevent soma loss but not axon degeneration.

This paper characterizes cerebrovascular phenotypes in WSB.APP/PS1 mice, showing age-related CAA, transcriptomic overlap with human AD, myelin deficits, and APOE allele-dependent effects on vascular pathology.

This study examines retinal aging across nine genetically diverse mouse strains, identifying molecular aging signatures and validating WSB and NZO as models for retinal neurodegenerative diseases.

This study shows that microglia depletion in aged mice increases optic nerve damage in glaucoma models, suggesting microglia protect against ocular hypertension-induced retinal ganglion cell loss.

This study investigates the role of PP1β in neuronal function by deleting it in mice, revealing its impact on myelination, glutamate release, and action potential propagation.

This study shows that metabolic syndrome in NZO mice reduces microglial plasticity and increases vascular interactions compared to B6J mice.

This study investigates the role of DDIT3 in RGC somal loss and axonal degeneration in DBA/2J mice with chronic ocular hypertension, finding that DDIT3 contributes to somal loss but not axonal degeneration.