Kai-Hui Yao

This study uses gene-edited hematopoietic stem cells to create long-lived B lymphocyte protein factories that produce therapeutic antibodies against HIV-1, malaria, and influenza.

This study shows that secreted antibodies significantly diversify primary and secondary humoral immune responses in mice, even at low antibody levels, with implications for vaccine design.

The paper shows that late-entering B cells in germinal centers mainly become memory B cells that recognize less common antigen parts.