Author

Erica J. Melief

University of WashingtonORCID 0000-0002-3570-3289Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 7 Research Focus:cell type annotation· 6 Approach:statistical model· 4 Approach:experimental assay· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Assay:electronic health records· 2 Approach:machine learning (classical)· 2

Frequent Co-Authors

Augustin RuiziD· 6 shared Delissa McMilleniD· 6 shared Jeff GoldyiD· 6 shared Brian E. KalmbachiD· 5 shared Brian LongiD· 5 shared Christina Alice PomiD· 5 shared Christopher Dirk KeeneiD· 5 shared Darren BertagnolliiD· 5 shared

Activity by Year

2020-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersNeuroscience

Augustin RuizORCID

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Author profile →

7 papers

Recent·Most cited

Multiregional single-cell profiling reveals shared and specialized cellular vulnerability in Alzheimer's disease

Kyle J. Travaglini, Mariano I. Gabitto, Yi Ding, Anamika Agrawal, Nadia O. Postupna, Joseph T. Mahoney, Eitan S Kaplan, Erica J. Melief, Jeff Goldy, Anish Bhaswanth Chakka, Ming Xiao, Tejas S Bajwa, Andreas Tjärnberg, Jeanelle Ariza, Song‐Lin Ding, , Ed S. Lein

This study uses single-nucleus RNA-seq, ATAC-seq, and Multiome to analyze Alzheimer's disease across multiple brain regions, revealing shared and region-specific cellular vulnerabilities.

bioRxiv · Jul 2, 2026 · PreprintNeuroscience

The Caudate Nucleus Exhibits Distinct Pathology and Cell Type-Specific Responses Across Alzheimer's Disease

Omar Z. Kana, Nadia O. Postupna, Anamika Agrawal, Brian Long, Kyle J. Travaglini, Mariano I. Gabitto, Hsin-Yu Lai, Joseph T. Mahoney, Ming Xiao, Tejas S Bajwa, Heino Hulsey-Vincent, Sora L Oyaizu, Gonzalo E. Mena, Janna Hong, Emily C. Gelfand, , Jennie Close

The paper maps AD-related pathological changes in the caudate nucleus at cellular resolution, identifying distinct features and cell type-specific responses.

bioRxiv · Jan 15, 2026 · PreprintNeuroscience

Integrated multimodal cell atlas of Alzheimer's disease

Mariano I. Gabitto, Kyle J. Travaglini, Victoria M. Rachleff, Eitan S Kaplan, Brian Long, Jeanelle Ariza, Yi Ding, Joseph T. Mahoney, Nick Dee, Jeff Goldy, Erica J. Melief, Anamika Agrawal, Omar Z. Kana, Xingjian Zhen, Samuel T. Barlow, , Kimberly A. Smith

This study creates an integrated multimodal cell atlas of Alzheimer's disease by analyzing single nuclei transcriptomes, epigenomes, and spatial coordinates across AD stages.

Nature Neuroscience · Oct 14, 2024Peer-reviewedGenomics

Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology

Harshvardhan Gazula, Henry F. J. Tregidgo, Benjamin Billot, Yaël Balbastre, Jonathan Williams-Ramirez, Rogeny Herisse, Lucas J Deden-Binder, Adrià Casamitjana, Erica J. Melief, Caitlin S. Latimer, Mitchell D. Kilgore, Mark Montine, Eleanor Robinson, Emily Blackburn, Michael S Marshall, , Juan Eugenio Iglesias

The paper develops open-source tools for 3D analysis of brain dissection photographs and surface scans, achieving accurate reconstructions and segmentations comparable to MRI.

eLife · Dec 12, 2023Peer-reviewedNeuroscience

Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

Thomas Chartrand, Rachel A. Dalley, Jennie Close, Natalia A. Goriounova, Brian Lee, Rusty Mann, Jeremy A. Miller, Gábor Molnár, Alice Mukora, Lauren Alfiler, Katherine S. Baker, Trygve E. Bakken, Jim Berg, Darren Bertagnolli, Thomas Braun, , Ed S. Lein

The paper identifies transcriptomic and morpho-electric diversity in human neocortical layer 1 interneurons, revealing greater subclass distinction compared to mouse.

Science · Oct 12, 2023Peer-reviewedNeuroscience

Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex

Brian Lee, Rachel A. Dalley, Jeremy A. Miller, Thomas Chartrand, Jennie Close, Rusty Mann, Alice Mukora, Lindsay Ng, Lauren Alfiler, Katherine S. Baker, Darren Bertagnolli, Krissy Brouner, Tamara Casper, Éva Csajbók, Nicholas P. Donadio, , Ed S. Lein

The paper uses viral labeling and Patch-seq to define morpho-electric properties of GABAergic interneurons in human neocortex, revealing functional insights and reclassifying some SST neurons into PVALB subclass.

Science · Oct 12, 2023Peer-reviewedNeuroscience

Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons

Jim Berg, Staci A. Sorensen, Jonathan T. Ting, Jeremy A. Miller, Thomas Chartrand, Anatoly Buchin, Trygve E. Bakken, Agata Budzillo, Nick Dee, Song‐Lin Ding, Nathan W. Gouwens, Rebecca D. Hodge, Brian E. Kalmbach, Changkyu Lee, Brian Lee, , Josef Šulc

The paper identifies transcriptomic diversity in human supragranular neurons and links it to functional specialization and disease vulnerability.

bioRxiv · Mar 31, 2020 · PreprintNeuroscience