Mu‐Shui Dai

GNL3 SUMOylation is essential for DNA double-strand break repair by homologous recombination

This study shows that GNL3 SUMOylation is essential for homologous recombination repair of DNA double-strand breaks and identifies potential therapeutic targets in breast cancer.

Global mRNA 3'UTR lengthening in small-cell neuroendocrine carcinoma

The paper identifies global 3'UTR lengthening in SCNC through APA and develops a neural network model to classify SCNC using APA signatures.

Tumor-intrinsic MHC-II activation in pancreatic ductal adenocarcinoma enhances immune response and treatment efficacy

This study shows that MHC-II expression in pancreatic cancer cells correlates with immune infiltration and improves immunotherapy response in mouse models.

MYC Serine 62 phosphorylation promotes its binding to DNA double strand breaks to facilitate repair and cell survival under genotoxic stress.

Phenotype-guided subpopulation identification from single-cell sequencing data

Scissor identifies cell subpopulations from single-cell data correlated with specific phenotypes using clinical information, revealing biologically relevant subpopulations in lung and melanoma cancers.