Matthew D. Baxter

REgulamentary is a tool for cell-type specific annotation of cis-regulatory elements, outperforming existing methods and applied to GWAS data to prioritize causal variants.

This study shows that high cholesterol induces epigenetic changes in hematopoietic stem cells that persist after cholesterol reduction, leading to systemic immunometabolic dysfunction.

REnformer predicts chromatin accessibility from single-cell ATAC-seq data, outperforming Enformer in accuracy and error rates, and validates its utility with a known thalassemia variant.

CREST-GV prioritizes disease-relevant cell types by analyzing genetic variants intersecting open chromatin regions across hundreds of cell types.

This study identifies BUD23 as a regulator of energy homeostasis by controlling translation of mitochondrial and lipogenic mRNAs, linking ribosomal modification to metabolic health.