Wei Shao

This study uses ultra-deep single-genome sequencing to show strong purifying selection in early HIV-1 infection, with limited early genetic divergence from founder viruses.

The paper compares HIV-1 proviral defects in children and adults on ART, finding more deletions and defects in children, especially in env and tat regions.

The paper compares the fraction and total number of HIV-infected cells with unspliced RNA in controllers and non-controllers, finding that viremic control is linked to fewer infected cells, not a lower fraction of infected cells with HIV usRNA.

The paper identifies large T-cell clones producing infectious HIV-1 virus as a source of non-suppressible viremia despite ART adherence and no drug resistance.

HIV-DRLink detects linked HIV-1 drug resistance mutations in next-generation sequencing data to predict treatment failure.