Author

Adam A. Capoferri

National Cancer InstituteORCID 0000-0002-6048-2115Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Mary F. KearneyiD· 4 shared Brian T. LukeiD· 3 shared John M. CoffiniD· 3 shared John W. MellorsiD· 3 shared Wei ShaoiD· 3 shared Jason W. RauschiD· 2 shared Michael J. BaleiD· 2 shared Rebecca HohiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersMicrobiology

Mary F. KearneyORCID

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4 papers

Recent·Most cited

Ultrasensitive single-genome sequencing reveals strong purifying selection in acute HIV-1 infection

Adam A. Capoferri, Valerie F. Boltz, Wei Shao, Clarissa Halpern, Rasmi Thomas, Nittaya Phanuphak, Lydie Trautmann, Sandhya Vasan, Carlo Sacdalan, Somchai Sriplienchan, John W. Mellors, John M. Coffin, Jason W. Rausch, Mary F. Kearney

This study uses ultra-deep single-genome sequencing to show strong purifying selection in early HIV-1 infection, with limited early genetic divergence from founder viruses.

bioRxiv · Aug 26, 2026 · PreprintMicrobiology

In vivo detection of HIV-1 antisense transcripts in untreated and ART-treated individuals

Adam A. Capoferri, Rachel Sklutuis, Toluleke Oloruntobi Famuyiwa, Sachi Pathak, Rui Li, Jason W. Rausch, Brian T. Luke, Rebecca Hoh, Steven G. Deeks, John W. Mellors, John M. Coffin, Jennifer L. Groebner, Fabio Romerio, Mary F. Kearney

This study detects HIV-1 antisense transcripts in vivo, showing higher expression in ART-treated individuals compared to untreated ones, suggesting a regulatory role in viral expression.

Life Science Alliance · Jul 14, 2025Peer-reviewedMicrobiology

Differential HIV-1 Proviral Defects in Children vs. Adults on Antiretroviral Therapy

Jenna M. Hasson, Mary Grace Katusiime, Adam A. Capoferri, Michael J. Bale, Brian T. Luke, Wei Shao, Mark Fredric Cotton, Gert Uves van Zyl, Sean C. Patro, Mary F. Kearney

The paper compares HIV-1 proviral defects in children and adults on ART, finding more deletions and defects in children, especially in env and tat regions.

Viruses · Jul 9, 2025Peer-reviewedMicrobiology

HIV-1 control in vivo is related to the number but not the fraction of infected cells with viral unspliced RNA

Adam A. Capoferri, Ann P. Wiegand, Feiyu F. Hong, Jana L. Jacobs, Jonathan Spindler, Andrew Musick, Michael J. Bale, Wei Shao, Michele D. Sobolewski, Anthony Richard Cillo, Brian T. Luke, Christine M. Fennessey, Robert J. Gorelick, Rebecca Hoh, Elias Konstantine Halvas, , Mary F. Kearney

The paper compares the fraction and total number of HIV-infected cells with unspliced RNA in controllers and non-controllers, finding that viremic control is linked to fewer infected cells, not a lower fraction of infected cells with HIV usRNA.

Proceedings of the National Academy of Sciences · Aug 27, 2024Peer-reviewedMicrobiology