Author

Soroush Hajizadeh

Broad InstituteORCID 0000-0002-4232-4690Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Robert Tyler MorrisiD· 2 shared Wilhelm HaasiD· 2 shared Alexandra N. MelloniiD· 1 shared Andrew E. H. EliaiD· 1 shared Ben K. Wesley· 1 shared Ben S. WittneriD· 1 shared Beverly L. DavidsoniD· 1 shared Bradley T. HymaniD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

Robert Tyler MorrisORCID

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2 papers

Recent·Most cited

The E3 ligase HECTD4 regulates COX-2 dependent tumor progression and metastasis

Joanna A. Vuille, Cem Tanrıöver, Ezgi Antmen, Douglas Scott Micalizzi, Richard Y. Ebright, Sambhavi Animesh, Robert Tyler Morris, Soroush Hajizadeh, Zachary J. Nicholson, Hunter C. Russell, Eric F. Zaniewski, Ben S. Wittner, Ben K. Wesley, Ji Eun Kwak, Julian Grünewald, , Daniel A. Haber

The paper identifies HECTD4 as a tumor and metastasis suppressor that targets COX-2 for degradation, with COX-2 stabilization driving pro-tumorigenic effects in breast cancer.

Proceedings of the National Academy of Sciences · Aug 6, 2025Peer-reviewedCancer Biology

APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease

Rosemary J. Jackson, Megan S. Keiser, Jonah C Meltzer, Dustin P. Fykstra, Steven E. Dierksmeier, Soroush Hajizadeh, Johannes Kreuzer, Robert Tyler Morris, Alexandra N. Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T. Ranum, Ellie M. Carrell, YongHong Chen, Maryam A. Nishtar, , Bradley T. Hyman

This paper shows that APOE2 gene therapy reduces amyloid deposition, neurodegeneration, and microglial activation in an Alzheimer's mouse model with ongoing APOE4 expression.

Molecular Therapy · Mar 18, 2024Peer-reviewedNeuroscience