APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease
Rosemary J. Jackson, Megan S. Keiser, Jonah C Meltzer, Dustin P. Fykstra, Steven E. Dierksmeier, Soroush Hajizadeh, Johannes Kreuzer, Robert Tyler Morris, Alexandra N. Melloni, Tsuneo Nakajima, Luis Tecedor, Paul T. Ranum, Ellie M. Carrell, YongHong Chen, Maryam A. Nishtar, , Bradley T. Hyman
This paper shows that APOE2 gene therapy reduces amyloid deposition, neurodegeneration, and microglial activation in an Alzheimer's mouse model with ongoing APOE4 expression.
Molecular Therapy · Mar 18, 2024Peer-reviewedNeuroscience