Author

Kelly M. Loyet

GenentechORCID 0000-0002-3733-099XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Alessandra CastiglioniiD· 2 shared Cecilia ChiuiD· 2 shared Jianhuan Zhang· 2 shared Matthieu MasureeliD· 2 shared Minh Thai· 2 shared Caroline WhittyiD· 1 shared Dean SheppardiD· 1 shared Dhaya SeshasayeeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Alessandra CastiglioniORCID

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2 papers

Recent·Most cited

Inhibition of integrin αvβ8-mediated TGFβ activation and active-TGFβ blockade promote anti-tumor immunity through distinct biological mechanisms

Kate Williams, Stephanie Mittman, Natalie S. Firmino, Jasmine W. Larrick, Zhe Zhang, Caroline Whitty, Hsiao‐Yen Ma, Xin Ren, Cecilia Chiu, Yagai Yang, Jianhuan Zhang, Minh Thai, Helena Païdassi, Matthieu Masureel, Kelly M. Loyet, , Alessandra Castiglioni

The paper shows that blocking integrin αvβ8 suppresses TGFβ in tumor-draining lymph nodes and enhances DC-T cell activation, offering a new immunotherapy strategy distinct from TGFβ ligand blockade.

bioRxiv · Jul 9, 2026 · PreprintImmunology

A Co-culture Cell-Based Reporter Assay for Quantitative Measurement of Integrin αvβ8-Mediated Activation of Latent TGF-β1

Jianhuan Zhang, Minh Thai, Matthieu Masureel, Cecilia Chiu, WeiYu Lin, Tulika Tyagi, Alessandra Castiglioni, Dhaya Seshasayee, Kelly M. Loyet

This paper develops a co-culture assay to measure integrin αvβ8-mediated activation of latent TGF-β1, showing it is sensitive and effective for screening antibodies.

bioRxiv · Jul 3, 2026 · PreprintImmunology