Author

Matthieu Masureel

GenentechORCID 0000-0002-4059-6166Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:GWAS / association mapping· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Alessandra CastiglioniiD· 2 shared Cecilia ChiuiD· 2 shared Jianhuan Zhang· 2 shared Kelly M. LoyetiD· 2 shared Minh Thai· 2 shared AJ VenkatakrishnaniD· 1 shared Asuka InoueiD· 1 shared Brian K. KobilkaiD· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

Alessandra CastiglioniORCID

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Author profile →

4 papers

Recent·Most cited

Inhibition of integrin αvβ8-mediated TGFβ activation and active-TGFβ blockade promote anti-tumor immunity through distinct biological mechanisms

Kate Williams, Stephanie Mittman, Natalie S. Firmino, Jasmine W. Larrick, Zhe Zhang, Caroline Whitty, Hsiao‐Yen Ma, Xin Ren, Cecilia Chiu, Yagai Yang, Jianhuan Zhang, Minh Thai, Helena Païdassi, Matthieu Masureel, Kelly M. Loyet, , Alessandra Castiglioni

The paper shows that blocking integrin αvβ8 suppresses TGFβ in tumor-draining lymph nodes and enhances DC-T cell activation, offering a new immunotherapy strategy distinct from TGFβ ligand blockade.

bioRxiv · Jul 9, 2026 · PreprintImmunology

A Co-culture Cell-Based Reporter Assay for Quantitative Measurement of Integrin αvβ8-Mediated Activation of Latent TGF-β1

Jianhuan Zhang, Minh Thai, Matthieu Masureel, Cecilia Chiu, WeiYu Lin, Tulika Tyagi, Alessandra Castiglioni, Dhaya Seshasayee, Kelly M. Loyet

This paper develops a co-culture assay to measure integrin αvβ8-mediated activation of latent TGF-β1, showing it is sensitive and effective for screening antibodies.

bioRxiv · Jul 3, 2026 · PreprintImmunology

Membrane phosphoinositides allosterically tune β-arrestin dynamics to facilitate GPCR core engagement

John Janetzko, Jonathan C. Deutsch, Yuqi Shi, Dirk H. Siepe, Matthieu Masureel, Weijing Liu, Rosa Viner, Asuka Inoue, Steven Chu, Brian K. Kobilka, Rabindra V. Shivnaraine

This study reveals that membrane phosphoinositides allosterically regulate β-arrestin dynamics, enabling engagement with minimally phosphorylated GPCRs.

bioRxiv · Jun 6, 2025 · PreprintBiophysics

Medical relevance of common protein-altering variants in GPCR genes across 337,205 individuals in the UK Biobank

Christopher DeBoever, AJ Venkatakrishnan, Joseph M. Paggi, Franziska M. Heydenreich, Suli‐Anne Laurin, Matthieu Masureel, Yosuke Tanigawa, Guhan Ram Venkataraman, Michel Bouvier, Ron O. Dror, Manuel A. Rivas

The paper identifies 138 associations between common protein-altering variants in GPCR genes and various phenotypes using UK Biobank data.

bioRxiv · Dec 13, 2019 · PreprintGenetics