Dylan R. Farnsworth

Cross hybridization Inference for Phylogenetic Resolution (CIPHR)-FISH enables microbiome imaging with strain level taxonomic resolution

CIPHR-FISH improves microbiome imaging by enabling strain-level taxonomic resolution through machine learning and probe design, revealing spatial community structures in zebrafish.

Loss of αBa-crystallin, but not αA-crystallin, increases age-related cataract in the zebrafish lens

This study shows that loss of zebrafish Ba-crystallin (cryaba) increases age-related cataract, while loss of A-crystallin (cryaa) does not, highlighting an ontogenetic shift in crystallin function during lens development.

Electrical synapse formation is differentially regulated by distinct isoforms of a postsynaptic scaffold

The paper shows that different isoforms of the ZO1b gene contribute uniquely to the electrical synapse density complex, affecting gap junction channel localization and function in zebrafish.

Connexinplexity: The spatial and temporal expression of connexin genes during vertebrate organogenesis

The paper maps the spatial and temporal expression of connexin genes in zebrafish during organogenesis, revealing tissue- and cell-type-specific patterns and providing a guide for human connexin genes.

Single cell transcriptomics of the developing zebrafish lens and identification of putative controllers of lens development

This study presents a single-cell transcriptomic atlas of zebrafish lens development, identifying novel regulators and expression patterns of crystallin and other genes.

An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities

The paper identifies zebrafish orthologs of the RAAS system and shows they are expressed in a specific intestinal cell type relevant to COVID-19 comorbidities.

A Single-Cell Transcriptome Atlas for Zebrafish Development

This paper creates a single-cell transcriptome atlas of zebrafish development, identifying 220 cell clusters and providing gene expression insights across four days of development.