Mathew A. Harris

General cognitive function and the brain's structural connectome

The paper shows that general cognitive function is supported by a widespread white matter network across multiple brain regions and connectivity measures.

General and specific patterns of cortical gene expression as substrates of complex cognitive functioning

The paper identifies general and specific patterns of cortical gene expression related to cognitive functioning using principal component analysis and validates them across datasets.

Integrated methylome and phenome study of the circulating proteome reveals markers pertinent to brain health

The paper identifies DNA methylation and proteomic markers associated with brain health through integrated methylome and phenome analyses.

Blood-based epigenome-wide analyses of cognitive abilities

This study identifies DNA methylation predictors of cognitive function using blood samples, showing they explain variance in cognitive ability and associate with biological markers.

Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life.

This study identifies three dimensions of cortical ageing in the human brain and links the most general dimension to cognitive decline across multiple domains in older adults.

Age-dependent genetic variants associated with longitudinal changes in brain structure across the lifespan

This study identifies genetic variants linked to longitudinal brain structure changes across the lifespan using MRI data from 15,640 individuals.

The genetic architecture of the human cerebral cortex

The paper identifies genetic loci associated with human cortical structure and finds genetic correlations with neuropsychiatric disorders.

Longitudinal trajectories of brain age in young individuals at familial risk of mood disorder

The paper examines brain age trajectories in young individuals with and without familial risk of mood disorder, finding decelerated brain maturation in those who later develop the disorder.

Enhanced prediction of cognitive function using aging-sensitive networks within the human structural connectome

The paper examines how aging affects brain network integrity and its association with cognitive function using MRI data from two cohorts.

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

The paper reports epigenome-wide meta-analyses of blood DNA methylation with subcortical brain volumes, identifying significant associations with hippocampal volume and potential biological mechanisms.

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

The paper identifies a neurobiological distinction in MDD subtypes based on SCZ polygenic risk, showing varying RACC thickness differences between MDD cases and controls.

Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium

The paper identifies 161 genome-wide significant genetic associations for cortical structure traits across 34 brain regions, highlighting key biological pathways and gene functions.

Planar cell polarity pathway and development of the human visual cortex

The paper identifies genetic associations with cortical surface area using PCA and GWAS, linking DAAM1 to visual cortex development through mitochondrial pathways and thalamocortical input.

Associations between vascular risk factors and brain MRI indices in UK Biobank

This study examines associations between vascular risk factors and brain MRI indices in UK Biobank, finding that higher vascular risk is linked to poorer brain health across macro- and microstructural measures.

Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

Across 5,216 UK Biobank adults, males had larger brain volumes and surface areas, females thicker cortices and stronger default-mode connectivity; male variance was generally greater.