Stephen M. Lawrie

Longitudinal White Matter Microstructure and Transition to Psychosis in Individuals at Clinical High Risk

The paper examines the relationship between white matter microstructure, measured by fractional anisotropy, and transition to psychosis in individuals at clinical high risk, finding directionally consistent but small associations.

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

Normative modeling of brain morphometry in Clinical High-Risk for Psychosis

This study examines brain morphometric deviations in individuals at clinical high-risk for psychosis and finds they largely overlap with healthy variation and are not strongly associated with symptom severity or conversion to psychosis.

Pathway-based polygenic risk scores for schizophrenia and associations with clinical and neuroimaging phenotypes in UK Biobank

This study calculates pathway-based polygenic risk scores for schizophrenia using gene-sets related to synaptic function and histone modification, and finds associations with neuroimaging and clinical traits in UK Biobank.

Psychotic-like experiences, polygenic risk scores for schizophrenia and structural properties of the salience, default mode and central-executive networks in healthy participants from UK Biobank

The paper investigates associations between polygenic risk scores for schizophrenia, psychotic-like experiences, and structural brain network properties in healthy UK Biobank participants.

Expression quantitative trait loci-derived scores and white matter microstructure in UK Biobank: a novel approach to integrating genetics and neuroimaging

The paper associates eQTL-derived gene expression scores with white matter microstructure in UK Biobank, identifying 8 significant genetic proxies linked to structural connectivity traits.

Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction

The paper investigates the impact of a t(1;11) translocation on white matter integrity and oligodendrocyte-myelin function using DTI and cellular models.

Stratifying major depressive disorder by polygenic risk for schizophrenia in relation to structural brain measures

The paper identifies a neurobiological distinction in MDD subtypes based on SCZ polygenic risk, showing varying RACC thickness differences between MDD cases and controls.

Acquisition of visual priors and induced hallucinations in chronic schizophrenia

This study investigates perceptual priors and hallucinations in chronic schizophrenia using a visual statistical learning task, finding comparable prior acquisition but reduced hallucinations in patients.

Associations between vascular risk factors and brain MRI indices in UK Biobank

This study examines associations between vascular risk factors and brain MRI indices in UK Biobank, finding that higher vascular risk is linked to poorer brain health across macro- and microstructural measures.

DISC1 regulates N-Methyl-D-Aspartate receptor dynamics: Abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness

This study shows that a DISC1 mutation linked to mental illness disrupts NMDAR dynamics and synaptic function in neurons, affecting excitatory synapses and vesicle dynamics.

Resting-state connectivity and its association with cognitive performance, educational attainment, and household income in UK Biobank (N = 3,950)

The paper examines resting-state brain connectivity in UK Biobank data and finds associations with cognitive performance, educational attainment, and household income.

Autistic traits, but not schizotypy, predict overweighting of sensory information in Bayesian visual integration

The paper investigates how autistic and schizotypal traits affect Bayesian visual integration, finding that autistic traits are linked to more accurate sensory processing rather than weaker priors.

Sex Differences In The Adult Human Brain: Evidence From 5,216 UK Biobank Participants

Across 5,216 UK Biobank adults, males had larger brain volumes and surface areas, females thicker cortices and stronger default-mode connectivity; male variance was generally greater.

Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and thalamic radiation white matter microstructure in UK Biobank

This study examines the association between polygenic risk scores for Major Depressive Disorder derived from the NETRIN1 pathway and whole-genome variants with white matter microstructure in the UK Biobank.

Genetic Architecture of Subcortical Brain Structures in Over 40,000 Individuals Worldwide

The paper identifies 25 genetic loci associated with subcortical brain structure volumes in over 40,000 individuals, revealing novel biology and potential drug targets.