Lynsey S. Hall

A genome-wide association study of 69,369 schizophrenia cases and 236,642 controls identifies 270 risk loci, prioritizes 130 genes, and links common and rare risk variants to neuronal synaptic biology.

This study identifies traits associated with polygenic risk for depression using UK Biobank data and finds causal links between depression risk and brain structure, as well as environmental interactions.

The paper investigates genetic risk factors for psychiatric and cognitive symptoms in Huntington’s Disease using polygenic risk scores and finds associations between specific psychiatric risk scores and corresponding symptoms.

This study performs a transcriptome-wide association study to link schizophrenia risk variants to gene expression in the dorsolateral prefrontal cortex, identifying 89 genes associated with pre- and post-synaptic abnormalities.

This study investigates whether genetic variation in the Major Histocompatibility Complex (MHC) is associated with depression risk, finding no significant associations at a conservative threshold.

The paper examines how genetic and environmental factors influence DNA methylation at variably methylated regions in neonatal blood, finding that combined effects best explain methylation variability.

This study integrates ASD GWAS summary statistics with gene expression data to identify differentially expressed genes in ASD and estimate heritability explained by predicted expression.

The paper analyzes rare and common alleles in schizophrenia trios, identifying rare missense variants in SLC6A1 and confirming the role of neurodevelopmental disorder genes.

This study shows that the length of uninterrupted CAG repeats, not the encoded polyglutamine segment, determines Huntington's disease onset, and DNA maintenance genes modify this process.

Genome-wide association meta-analysis of 130,664 major depression cases and 330,470 controls identifies 44 independent risk loci enriched in cortical neurons, conserved mammalian regions, splicing networks, and antidepressant targets.

The paper investigates the genetic and environmental contributions to stressful life events and their overlap with depression and neuroticism using a large family-based sample.

This study performs genome-wide meta-analyses of depression in two large cohorts, finding one significant locus and suggesting larger sample sizes may be more informative than phenotypic stratification.

This study performs a genome-wide haplotype-based association analysis for major depressive disorder using two cohorts, identifying significant haplotypes potentially linked to the disorder.

This study finds accelerated epigenetic ageing in major depressive disorder (MDD) cases compared to controls using the Horvath clock, partially mediated through BMI.

This study investigates shared genetic architecture between subcortical brain volumes and MDD using GWAS data from multiple cohorts, finding a non-significant positive genetic correlation for hippocampal volume.

This study conducts a GWAS of alcohol consumption in UK Biobank, identifying 8 loci, including novel associations, and reports genetic overlaps with schizophrenia, HDL cholesterol, smoking, and anthropometric traits.