Katarzyna M. Tyc

A genome-wide in vivo screen reveals fitness pathways required for streptococcal infective endocarditis

This study identifies 146 genes in Streptococcus sanguinis essential for infective endocarditis fitness, revealing conserved pathways and potential therapeutic targets.

HPV co-infection burden, vaginal microbiota restructuring, and host context are associated with Cervical precancer risk in a racially restricted observational cohort

The paper assesses how HPV burden, vaginal microbiota, and host factors predict CIN3 risk in a racially diverse cohort, finding that integrated models outperform HPV-only models.

Maternal genetic variants in kinesin motor domains prematurely increase egg aneuploidy

The study identifies genetic determinants of reproductive aging linked to egg aneuploidy by analyzing maternal exomes and shows kinesin gene variants contribute to aneuploidy and accelerated aging.

Proteolysis-targeting vaccines (PROTAVs) for robust combination immunotherapy of melanoma

This paper introduces PROTAVs, a new vaccine strategy that enhances T cell responses and combination immunotherapy for melanoma by improving antigen processing and cross-presentation.

Spatial Deconvolution of Cell Types and Cell States at Scale Utilizing TACIT

The paper introduces TACIT, an unsupervised algorithm for cell type annotation in spatial biology, showing improved accuracy and scalability across multiple datasets and applications.

Yin Yang 1 sets up the stage for cerebellar astrocyte maturation

This study identifies YY1's role in regulating cerebellar astrocyte maturation and maintenance in adult mice through single-cell RNA-seq analysis.

Chromatin conformation capture (Hi-C) sequencing of patient-derived xenografts: analysis guidelines

This study evaluates the impact of mouse read removal and library preparation on Hi-C data quality in patient-derived xenografts, finding that library strategy has the largest effect.