Mark Denham

This study shows BRD1 haploinsufficiency disrupts early neuronal programming and synaptic maturation in human induced glutamatergic neurons, leading to altered neurodevelopmental trajectories and increased neuronal activity.

The paper introduces MJF-14 PLA, a proximity ligation assay for detecting non-inclusion alpha-synuclein aggregates with high specificity and sensitivity, showing pathology precedes Lewy body formation in Parkinson's disease.

This study uses transgenic porcine models to show that APP and its AICD domain modulate AD-related gene networks through interactions with signaling proteins.

This study genetically modifies human pluripotent stem cells to generate lineage-restricted undifferentiated stem cells that efficiently produce mesencephalic dopaminergic neurons for potential clinical applications.

The paper uses single-cell RNA sequencing to study porcine medial entorhinal cortex development and demonstrates the production of human entorhinal stellate cell-like cells from pluripotent stem cells.