The paper integrates DNA methylation with clinical risk factors to improve mortality prediction, identifying CpG biomarkers associated with all-cause, cardiovascular, and cancer mortality.

Aging Cell · May 12, 2022Peer-reviewedGenetic & Genomic Medicine

Mapping genetic determinants of 184 circulating proteins in 26,494 individuals to connect proteins and disease.

Erin Macdonald-Dunlop, Lucija Klarić, Lasse Folkersen, Paul R. H. J. Timmers, Stefan Gustafsson, Jing Hua Zhao, Niclas Eriksson, Anne Richmond, Stefan Enroth, Niklas Mattsson, Daria V. Zhernakova, Anette Kalnapenkis, Martin Magnusson, Eleanor Wheeler, Shih‐Jen Hwang, , James F. Wilson

This study identifies 592 genetic loci associated with 184 plasma proteins in 26,494 individuals and finds causal relationships between protein levels and disease.

medRxiv · Aug 3, 2021 · PreprintGenetic & Genomic Medicine

Functional Characterization of Lipid Regulatory Effects of Three Genes Using Knockout Mouse Models

Chen Yao, Holly S. Savage, Tong Hao, Gha Young Lee, Yuka Takemon, Wenting Bian, DAVID EDWIN HILL, Marc Vidal, Ron Korstanje, Daniel A Levy

The paper identifies three causal lipid genes using Mendelian randomization and confirms their effects through mouse knockout studies and RNA-seq analysis.

medRxiv · Jul 1, 2021 · PreprintGenetic & Genomic Medicine

Genetically independent phenotype analysis identifies LPA and VCAM1 as drug targets for human ageing

Paul R. H. J. Timmers, Evgeny Tiys, Saori Sakaue, Masato Akiyama, Tuomo Kiiskinen, Wei Zhou, Shih‐Jen Hwang, Chen Yao, The Biobank Japan Project, FinnGen Study, Joris Deelen, Daniel A Levy, Andrea Ganna, Yoichiro Kamatani, Yukinori Okada, , Yakov A. Tsepilov

This study combines multiple GWAS of ageing traits to identify genetic components associated with human ageing and finds LPA and VCAM1 as potential drug targets.

bioRxiv · Jan 22, 2021 · PreprintGenomics

Cardiovascular Disease Related Proteomic Biomarkers of Alcohol Consumption

Xianbang Sun, Jennifer E. Ho, He Gao, Εvangelos Εvangelou, Chen Yao, Tianxiao Huan, Shih‐Jen Hwang, Paul L. Courchesne, Martin G. Larson, Daniel A Levy, Jiantao Ma, Chunyu Liu

This study identifies 20 alcohol-associated proteins and shows complex relationships between alcohol consumption, circulating proteins, and cardiovascular disease risk factors.

bioRxiv · Oct 17, 2020 · PreprintBioinformatics

Integrative Genomic Analysis and Functional Studies Reveal GP5, GRN, MPO and MCAM as Causal Protein Biomarkers for Platelet Traits

Dong Heon Lee, Chen Yao, Arunoday Bhan, Thorsten M. Schlaeger, Joshua A. Keefe, Benjamin A.T. Rodriguez, Shih‐Jen Hwang, Ming‐Huei Chen, Daniel A Levy, Andrew D. Johnson

The paper identifies four proteins causally linked to platelet traits using genomic, epidemiological, and experimental data.

bioRxiv · Nov 29, 2019 · PreprintGenomics