The paper identifies pQTLs for 91 plasma proteins, finds novel associations, and uses MR to uncover causal roles in immune-mediated diseases, suggesting new therapeutic targets.

Nature Immunology · Aug 10, 2023Peer-reviewedGenetic & Genomic Medicine

Mapping genetic determinants of 184 circulating proteins in 26,494 individuals to connect proteins and disease.

Erin Macdonald-Dunlop, Lucija Klarić, Lasse Folkersen, Paul R. H. J. Timmers, Stefan Gustafsson, Jing Hua Zhao, Niclas Eriksson, Anne Richmond, Stefan Enroth, Niklas Mattsson, Daria V. Zhernakova, Anette Kalnapenkis, Martin Magnusson, Eleanor Wheeler, Shih‐Jen Hwang, , James F. Wilson

This study identifies 592 genetic loci associated with 184 plasma proteins in 26,494 individuals and finds causal relationships between protein levels and disease.

medRxiv · Aug 3, 2021 · PreprintGenetic & Genomic Medicine

Genomic evaluation of circulating proteins for drug target characterisation and precision medicine

Lasse Folkersen, Stefan Gustafsson, Qin Wang, Daniel Hvidberg Hansen, Åsa K. Hedman, Andrew Joseph Schork, Karen M. Page, Daria V. Zhernakova, Yang Wu, James E. Peters, Niclas Ericsson, Sarah E. Bergen, Thibaud Boutin, Andrew D. Bretherick, Stefan Enroth, , Anders Mälarstig

The paper identifies pQTLs for cardiovascular proteins and uses them to evaluate drug targets and suggest new candidates for precision medicine.

bioRxiv · Apr 3, 2020 · PreprintGenetics

Expanded genetic landscape of chronic obstructive pulmonary disease reveals heterogeneous cell type and phenotype associations

Phuwanat Sakornsakolpat, Dmitry Prokopenko, Maxime Lamontagne, Nicola F. Reeve, Anna L. Guyatt, Victoria E. Jackson, Nick R. G. Shrine, Dandi Qiao, Traci M. Bartz, Deog Kyeom Kim, Mi Kyeong Lee, Jeanne C. Latourelle, Xingnan Li, Jarrett D. Morrow, Ma’en Obeidat, , Nicholas J. Wareham

This study expands the genetic landscape of COPD by identifying 82 risk loci, revealing associations with lung function, cell types, and comorbidities.

Nature Genetics · Feb 25, 2019Peer-reviewedGenetics

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

Nick R. G. Shrine, Anna L. Guyatt, Abdullah Mesut Erzurumluoglu, Victoria E. Jackson, Brian D. Hobbs, Carl Melbourne, Chiara Batini, Katherine A. Fawcett, Kijoung S Song, Phuwanat Sakornsakolpat, Xingnan Li, Ruth Boxall, Nicola F. Reeve, Ma’en Obeidat, Jing Hua Zhao, , Andrew P. Morris

The paper identifies 279 new genetic signals for lung function across multiple ancestries, showing associations with COPD and pleiotropic effects.

Nature Genetics · Feb 25, 2019Peer-reviewedGenomics

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Victoria E. Jackson, Jeanne C. Latourelle, Louise V. Wain, Albert V. Smith, Megan L. Grove, Traci M. Bartz, Ma’en Obeidat, Michael A. Province, Wei Dong Gao, Beenish Qaiser, David John Porteous, Patricia A. Cassano, Tarunveer S. Ahluwalia, Niels Grarup, Jin Li, , Sven Gläser

Wellcome Open Research · Jan 12, 2018Peer-reviewedGenetics

Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney

Louise V. Wain, Ahmad Vaez, Rick Jansen, Roby Joehanes, Peter J. van der Most, Abdullah Mesut Erzurumluoglu, Paul F. O’Reilly, Claudia P. Cabrera, Helen R. Warren, Lynda M. Rose, Germaine C. Verwoert, Jouke‐Jan Hottenga, Rona J. Strawbridge, Tõnu Esko, Dan E. Arking, , Tamara B. Harris

This study identifies 6 new blood pressure loci and 48 genes involved in BP regulation using GWAS and gene expression data from blood and kidney tissues.

Hypertension · Jul 24, 2017Peer-reviewedGenomics