This study identifies that 3q-gain aneuploidy in squamous cell carcinomas creates a vulnerability to SREBP-pathway inhibition, offering a target for lipid-targeted therapies.

bioRxiv · May 8, 2026 · PreprintCancer Biology

Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities

Yuka Takemon, Erin Pleasance, Alessia Gagliardi, Christopher S. Hughes, Veronika Csizmók, Kathleen Wee, Diane L.N. Trinh, Ryan D. Huff, Andrew J. J. Mungall, Richard A. Moore, Eric Chuah, Karen Mungall, Eleanor Lewis, Jessica Nelson, Howard John Lim, , Marco A. Marra

bioRxiv · Jan 17, 2024 · PreprintBioinformatics

GRETA: an R package for mapping in silico genetic interaction and essentiality networks

Yuka Takemon, Marco A. Marra

GRETA is an R package that enables in silico genetic interaction and essentiality network analyses using public data, with documentation and tutorials provided.

Bioinformatics · Jun 16, 2023Peer-reviewedBioinformatics

Functional Characterization of Lipid Regulatory Effects of Three Genes Using Knockout Mouse Models

Chen Yao, Holly S. Savage, Tong Hao, Gha Young Lee, Yuka Takemon, Wenting Bian, DAVID EDWIN HILL, Marc Vidal, Ron Korstanje, Daniel A Levy

The paper identifies three causal lipid genes using Mendelian randomization and confirms their effects through mouse knockout studies and RNA-seq analysis.

medRxiv · Jul 1, 2021 · PreprintGenetic & Genomic Medicine

Proteomic and transcriptomic profiling reveal different aspects of aging in the kidney

Yuka Takemon, Joel M. Chick, Isabela Gerdes Gyuricza, Daniel A. Skelly, Olivier Devuyst, Steven P. Gygi, Gary A. Churchill, Ron Korstanje

This study profiles mRNA and protein levels in aging kidneys, finding that protein changes reveal more extensive and functionally significant aging-related alterations than mRNA.

eLife · Mar 9, 2021Peer-reviewedSystems Biology