Author

Uwe Groß

Universitätsmedizin GöttingenORCID 0000-0001-9874-1007Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Antje DickmannsiD· 2 shared Dirk GörlichiD· 2 shared Kim M. StegmanniD· 2 shared Matthias DobbelsteiniD· 2 shared Stephanie PfaenderiD· 2 shared Alexander RiekiD· 1 shared Amelie Schreieck· 1 shared Angele BreithauptiD· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersMolecular Biology

Antje DickmannsORCID

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2 papers

Recent·Most cited

N4-hydroxycytidine and inhibitors of dihydroorotate dehydrogenase synergistically suppress SARS-CoV-2 replication

Kim M. Stegmann, Antje Dickmanns, Natalie Heinen, Claudia Blaurock, Tim Karrasch, Angele Breithaupt, Robert Klopfleisch, Nadja Uhlig, Valentina Eberlein, Leila Issmail, Simon T. Herrmann, Amelie Schreieck, Evelyn Peelen, Hella Kohlhof, Alexander Riek, , Matthias Dobbelstein

This paper shows that combining N4-hydroxycytidine and DHODH inhibitors strongly reduces SARS-CoV-2 replication in cell cultures.

bioRxiv · Jun 28, 2021 · PreprintMolecular Biology

The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models

Kim M. Stegmann, Antje Dickmanns, Sabrina Gerber, Vella Nikolova, Luisa Klemke, Valentina Manzini, Denise Schlösser, Cathrin Bierwirth, Julia Freund, Maren Sitte, Raimond Lugert, Gabriela Salinas, Toni Luise Meister, Stephanie Pfaender, Dirk Görlich, , Matthias Dobbelstein

This paper shows that methotrexate inhibits SARS-CoV-2 replication in cell cultures and synergizes with remdesivir, suggesting potential for repurposing MTX in treating COVID-19.

Virus Research · Jun 6, 2021Peer-reviewedMolecular Biology