Cancer BiologybioRxiv
Degradation of LMO2 in T cell leukaemia results in collateral breakdown of transcription complex partners and causes LMO2-dependent apoptosis
Naphannop Sereesongsaeng, Carole J. R. Bataille, Angela J. Russell…·Terence Howard Rabbitts
This study shows that degrading LMO2 in T cell leukemia leads to loss of its DNA-binding partners and apoptosis, suggesting therapeutic potential for LMO2-targeting drugs.
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