Sabrine Hédouin

Native yeast kinetochore structures identify an essential inner kinetochore interaction

The paper identifies an essential Ndc10 trimerization interaction in yeast kinetochores that stabilizes centromeric DNA and facilitates kinetochore assembly.

An interdependent Cbf1-CCAN interaction stabilizes the budding yeast kinetochore

This study identifies an interdependent Cbf1-CCAN interaction that stabilizes the budding yeast kinetochore by coupling transcriptional roadblocking to inner kinetochore assembly.

Centromeres in the thermotolerant yeast K. marxianusmediate attachment to a single microtubule

This study shows that K. marxianus has a single centromeric nucleosome that mediates attachment to one microtubule, similar to S. cerevisiae.

Conservation of dichromatin organization along regional centromeres

The paper uses Fiber-seq to show that regional centromeres have dichromatin organization, with accessible and compacted chromatin, which is conserved across species despite DNA sequence differences.

Stable centromere association of the yeast histone variant Cse4 requires its essential N-terminal domain

The paper investigates how the N-terminal domain of Cse4 stabilizes its association with centromeres in yeast, showing that OA and Scm3 independently stabilize Cse4 through their interactions with the END region.