A painless nerve growth factor variant uncouples nociceptive and neurotrophic TrkA signaling
Shailesh Kumar, Harry Jung, Gerard Walker, Jaimin K. Rana, Rui Fu, Minh Triết Hồng, Francesca Malerba, Jyotsna Kumar, Vikas Navratna, Wonhyeuk Jung, Sean Miller, Lukas M. Kruckenhauser, Simona Capsoni, Brian P. Hafler, Antonino Cattaneo, , Moitrayee Bhattacharyya
This paper identifies a NGF variant that selectively biases TrkA signaling towards neurotrophic functions without triggering pain, revealing mechanisms for therapeutic targeting of the NGF-TrkA pathway.
bioRxiv · Nov 18, 2025 · PreprintNeuroscience