This study examines polygenic scores for schizophrenia and major depression in Chinese adults, finding associations with various traits and highlighting ancestry-specific genetic correlations.

Biological Psychiatry Global Open Science · Dec 22, 2025Peer-reviewedGenetic & Genomic Medicine

Stratifying Lung Adenocarcinoma Risk with Multi-ancestry Polygenic Risk Scores in East Asian Never-Smokers

Batel Blechter, Xiaoyu Wang, Juncheng Dai, Christiana Kartsonaki, Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo, Tzu‐Yu Chen, Rayjean J. Hung, Kexin Chen, Xiao-Ou Shu, Young Tae Kim, Parichoy Pal Choudhury, Jacob Williams, , Ping Yang

The paper develops and validates multi-ancestry polygenic risk scores for LUAD in East Asian never-smokers, showing improved risk prediction compared to East Asian-only models.

JNCI Journal of the National Cancer Institute · Sep 18, 2025Peer-reviewedGenetic & Genomic Medicine

Genome-wide characterization of circulating metabolic biomarkers reveals substantial pleiotropy and novel disease pathways

Minna K. Karjalainen, Savita Karthikeyan, Clare Oliver‐Williams, Eeva Sliz, Elias Allara, Praveen Surendran, Weihua Zhang, Pekka Jousilahti, Kati Kristiansson, Veikko V Salomaa, Matt Goodwin, David A. Hughes, Michael Boehnke, Lilian Fernandes Silva, Xianyong Yin, , Johannes Kettunen

This study identifies 400+ genetic loci associated with circulating metabolic traits and highlights pleiotropy and novel disease pathways.

medRxiv · Oct 20, 2022 · PreprintGenetic & Genomic Medicine

Trans-ancestry meta-analysis improves performance of genetic scores for multiple adiposity-related traits in East Asian populations

Zammy Fairhurst-Hunter, Kuang Lin, Iona Y. Millwood, Alfred Pozarickij, Tzu‐Ting Chen, Jason Torres, Jian-an Lun, Christiana Kartsonaki, Wei Gan, Anubha Mahajan, Huaidong Du, Rajani Sohoni, Yu Guo, Sam Sansome, Ling Yang, , Robin G. Walters

This paper improves genetic scores for adiposity traits in East Asian populations by using trans-ancestry meta-analysis, increasing variance explained compared to European-derived scores.

medRxiv · Jul 5, 2022 · PreprintGenetic & Genomic Medicine

The genetic architecture of sporadic and recurrent miscarriage

Triin Laisk, Ana Gonçalves Soares, Teresa Cruz Ferreira, Jodie N. Painter, Samantha Laber, Jonas Bačelis, Chia‐Yen Chen, Maarja Lepamets, Kuang Lin, SiYang Maggie Liu, Iona Y. Millwood, Avinash Ramu, Jennifer H. Southcombe, Marianne Andersen, Ling Yang, , Cecilia M. Lindgren

This study identifies genetic variants associated with sporadic and recurrent miscarriage through large-scale association analyses and Mendelian randomization.

bioRxiv · Mar 12, 2019 · PreprintGenetics