Author

Zhengzhi Liu

Virginia TechORCID 0000-0002-7650-5502Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 5 Approach:experimental assay· 5 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Organism:human· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

Chang LuiD· 6 shared Bohan ZhuiD· 4 shared Chengyu DengiD· 3 shared J. Javier MeanaiD· 3 shared Javier González‐MaesoiD· 3 shared Zirui ZhouiD· 3 shared Gaoshan LiiD· 2 shared Lynette B. NaleriD· 2 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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6 shared papersGenomics

Chang LuORCID

Mutual co-authors in cluster

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6 papers

Recent·Most cited

Microfluidic low-input profiling reveals lncRNA roles in disease

Jenna A. Catalano, Yuan-Pang Hsieh, Zhengzhi Liu, Gaoshan Li, J. Javier Meana, Javier González‐Maeso, Zhen Chen, Chang Lu

The paper introduces a low-input microfluidic method to profile lncRNA-chromatin interactions in disease-relevant tissues and cell types, revealing distinct roles of two lncRNAs in schizophrenia.

bioRxiv · Mar 22, 2026 · PreprintGenomics

Comprehensive multimodal and multiomic profiling reveals epigenetic and transcriptional reprogramming in lung tumors

Peiyao Wu, Zhengzhi Liu, Lina Zheng, Yanmiao Du, Zirui Zhou, Wei Wang, Chang Lu

The paper integrates epigenomic and transcriptomic data from lung tumors and non-neoplastic tissues to identify cancer-related signaling networks and regulatory changes.

Communications Biology · Mar 31, 2025Peer-reviewedGenomics

Antipsychotic-induced epigenomic reorganization in frontal cortex of individuals with schizophrenia

Bohan Zhu, Richard I. Ainsworth, Zengmiao Wang, Zhengzhi Liu, Salvador Sierra, Chengyu Deng, Luis Felipe Callado, J. Javier Meana, Wei Wang, Chang Lu, Javier González‐Maeso

The paper identifies epigenetic changes in frontal cortex of schizophrenia patients, showing antipsychotic treatment reverses some alterations and amplifies age effects.

eLife · Dec 7, 2023Peer-reviewedNeuroscience

Droplet-based bisulfite sequencing for high-throughput profiling of single-cell DNA methylomes

Qiang Zhang, Sai Ma, Zhengzhi Liu, Bohan Zhu, Zirui Zhou, Gaoshan Li, J. Javier Meana, Javier González‐Maeso, Chang Lu

This paper introduces Drop-BS, a droplet-based microfluidic method for single-cell bisulfite sequencing, enabling high-throughput DNA methylome profiling of up to 10,000 cells in 2 days.

Nature Communications · Aug 3, 2023Peer-reviewedGenomics

Epigenomic tomography for probing spatially-defined molecular state in the brain

Zhengzhi Liu, Chengyu Deng, Zirui Zhou, Ya Xiao, Shan Jiang, Bohan Zhu, Lynette B. Naler, Xiaoting Jia, Danfeng Daphne Yao, Chang Lu

This paper introduces a method to map spatial epigenomic variations in brain tissue at a centimeter scale, revealing dynamic changes in specific brain regions due to seizures.

bioRxiv · Nov 24, 2022 · PreprintGenomics

Native MOWChIP-seq: Genome-wide profiles of key protein bindings reveal functional differences among various brain regions

Zhengzhi Liu, Lynette B. Naler, Yan Zhu, Chengyu Deng, Qiang Zhang, Bohan Zhu, Zirui Zhou, Mimosa Sarma, Alexander Murray, Hehuang Xie, Chang Lu

The paper introduces native MOWChIP-seq, a low-input ChIP-seq method, and applies it to study protein binding differences between mouse brain regions.

bioRxiv · Jul 11, 2021 · PreprintGenomics