Author

Herbert Kim Lyerly

Duke UniversityORCID 0000-0002-0063-4770Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cancer Biology· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

Joshua C. SnyderiD· 3 shared Joshua D. GinzeliD· 3 shared Alexander D. BorowskyiD· 2 shared Bruce W. RogersiD· 2 shared Henry Chapman· 2 shared Joelle E. Sills· 2 shared Alejandra V. PatinoiD· 1 shared Allison J. Introne· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

Joshua C. SnyderORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

P95-HER2 promotes metastatic progression by biasing MRTFA dependent signaling

Joseph D. Fernandes, Erin R. Bresnahan, Hillary Zawada, Joshua D. Ginzel, Herbert Kim Lyerly, Bruce Rogers, Shyam M. Kavuri, Allison J. Introne, Melanie R Sadecki, Hidetoshi Mori, Glenn Doherty, Alexander D. Borowsky, Kevin Flores, Jose Javier Bravo‐Cordero, Joshua C. Snyder

This study shows that the p95 isoform of HER2 promotes metastasis by biasing MRTFA-dependent signaling through specific tyrosine phosphorylation.

bioRxiv · Jul 23, 2026 · PreprintCell Biology

A Precision Ultrasound-Localized Sonoporation-Equipment (PULSE) Enabling Intratumoral Delivery for Cancer Immunotherapy

Mengyue Chen, Bohua Zhang, Howuk Kim, Benjamin C. Kreager, Waston Yang, Keren Zhao, Sunho Moon, Huaiyu Wu, Erika J. Crosby, Takuya Osada, Jingjie Hu, Herbert Kim Lyerly, Xiaoning Jiang

The paper introduces PULSE, a device for targeted ultrasound-mediated delivery of drugs and genes in tumors, showing improved transfection and perfusion in vitro and phantom tests.

bioRxiv · Jul 22, 2025 · PreprintBioengineering

CoSiDeX: A hyperspectral fluorescent protein resource for highly multiplexed imaging

Alejandra V. Patino, Henry Chapman, Joshua D. Ginzel, Joelle E. Sills, Herbert Kim Lyerly, Bruce W. Rogers, Joaquín E. Drut, Joshua C. Snyder

The paper introduces CoSiDeX, a tool for selecting and decoding fluorescent protein palettes in multiplexed imaging experiments using hyperspectral data.

bioRxiv · May 9, 2025 · PreprintMolecular Biology

Nonlinear progression during the occult transition establishes cancer lethality

Joshua D. Ginzel, Henry Chapman, Joelle E. Sills, Edwin J. Allen, Larry S. Barak, Robert D. Cardiff, Alexander D. Borowsky, Herbert Kim Lyerly, Bruce W. Rogers, Joshua C. Snyder

This study shows that cancer progression is nonlinear, with a critical occult transition leading to lethal tumors before detection, challenging the linear model of cancer growth.

Disease Models & Mechanisms · Mar 1, 2025Peer-reviewedCancer Biology