Joshua C. Snyder

P95-HER2 promotes metastatic progression by biasing MRTFA dependent signaling

This study shows that the p95 isoform of HER2 promotes metastasis by biasing MRTFA-dependent signaling through specific tyrosine phosphorylation.

β-Arrestin Condensates Regulate G Protein-Coupled Receptor Function

This study shows β-arrestin condensates regulate GPCR function through liquid-liquid phase separation, influencing internalization and signaling.

CoSiDeX: A hyperspectral fluorescent protein resource for highly multiplexed imaging

The paper introduces CoSiDeX, a tool for selecting and decoding fluorescent protein palettes in multiplexed imaging experiments using hyperspectral data.

Nonlinear progression during the occult transition establishes cancer lethality

This study shows that cancer progression is nonlinear, with a critical occult transition leading to lethal tumors before detection, challenging the linear model of cancer growth.

Adaptive selection of p53 mutation metaplastic phenotypes in estrogen-independent progression of ER+ tumors: A mechanism for acquired resistance to hormonal therapy.

This study shows that ER+ breast cancers can develop resistance to hormonal therapy through clonal selection of metaplastic p53-mutated basal cells in Stat1-/- mice.

Gut mucosal cells transfer alpha-synuclein to the vagus nerve

The paper shows that gut mucosal cells can transfer alpha-synuclein to the vagus nerve, suggesting a non-neuronal source of fibrillar alpha-synuclein in Parkinson's disease.

Measuring nonapoptotic caspase activity with a transgenic reporter in mice

The paper develops a transgenic mouse model with a fluorescent caspase activity reporter to quantify nonapoptotic caspase activity in rodent brains and demonstrates its use in studying neurophysiological and stress-related effects.