Lars Bertram

Genomics of Educational Attainment Across 80 Years of Social and Political Transformation in Germany

The paper examines how polygenic indices for educational attainment change across birth cohorts and regions in Germany, finding stronger associations in recent cohorts and the East but weaker effects for women.

ADHD and intelligence polygenic scores associations with developmental dimensions in children with attention, learning and memory difficulties

The paper examines associations between ADHD and intelligence polygenic scores and developmental dimensions in children with attention, learning, and memory difficulties, finding significant links with cognitive and behavioral traits.

GWAS on short tandem repeats identifies novel genetic mechanisms in Alzheimer's disease

This study conducts GWAS on short tandem repeats (STRs) to identify novel genetic mechanisms in Alzheimer's disease using data from ~330,000 individuals.

Biological age acceleration measured by DunedinPACE associates most consistently with cognitive decline in elderly individuals

This study finds that DunedinPACE, an epigenetic clock, most consistently associates with cognitive decline in older adults compared to other DNAm clocks and telomere length.

Matching Heterogeneous Cohorts by Projected Principal Components Reveals Two Novel Alzheimer's Disease-Associated Genes in the Hispanic Population

Context-dependent regulatory variants in Alzheimer's disease

The paper identifies context-dependent regulatory variants in Alzheimer's disease by analyzing their effects across different cellular contexts using MPRAs and machine learning.

Identification of lncRNAs differentially expressed in Alzheimer's disease brains using RNA sequencing

The paper identifies differentially expressed lncRNAs in Alzheimer's disease brains using RNA-seq data from multiple studies and brain regions.

Peripheral immune profiles in individuals at genetic risk for amyotrophic lateral sclerosis and Alzheimer's disease

The paper examines immune cell profiles in individuals with genetic risk for ALS and AD, finding nominally significant associations but no significant associations after FDR correction.

Molecular hallmarks of excitatory and inhibitory neuronal resilience and resistance to Alzheimer's disease

This study identifies molecular and cellular signatures of cognitive resilience in Alzheimer's disease by integrating multi-omics data from brain tissues.

Immune cell distributions in the blood of healthy individuals at high genetic risk of Parkinson's disease

The paper examines immune cell distributions in healthy individuals at high genetic risk of Parkinson's disease and finds no significant associations between polygenic risk scores and immune cell subtypes, though some nominally significant associations were observed.

Blood-based multivariate methylation risk score for cognitive impairment and dementia

The paper develops a multivariate methylation risk score using blood DNA methylation data to predict dementia risk and cognitive impairment in Alzheimer's and Parkinson's disease cohorts.

Genome-wide association study reveals different T cell distributions in peripheral blood of healthy individuals at high genetic risk of type 1 diabetes and long COVID

This paper conducts a GWAS to identify genetic loci associated with immune cell distributions in healthy individuals and links these to type 1 diabetes and long COVID risk.

Genome-wide QTL mapping across three tissues highlights several Alzheimer's and Parkinson's disease loci potentially acting via DNA methylation

The paper maps DNA methylation quantitative trait loci (meQTL) in three tissues and uses Mendelian randomization to link DNAm to Alzheimer's and Parkinson's disease risk.

Accelerated brain change in healthy adults is associated with genetic risk for Alzheimer's disease and uncovers adult lifespan memory decline

The paper shows that higher genetic risk for Alzheimer's disease is linked to faster brain volume loss and memory decline in healthy adults.

Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease

This study identifies four novel DNA methylation loci in the entorhinal cortex associated with Alzheimer's disease and finds significant epigenetic age acceleration in patients.

A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples

The paper correlates DNA methylation patterns between buccal and brain samples to identify CpG sites with significant methylation correlations and genetic determinants.

Common signatures of differential microRNA expression in Parkinson's and Alzheimer's disease brains

The paper assesses differential microRNA expression in Parkinson's and Alzheimer's disease brains, identifying shared miRNAs with potential pathogenic roles.

Differential microRNA expression analyses across two brain regions in Alzheimer's disease

The paper identifies differentially expressed miRNAs in two brain regions of Alzheimer's patients using qPCR and RNA-seq, highlighting potential targets involved in AD pathogenesis.

Genome-wide association study of Alzheimer's disease brain imaging biomarkers and neuropsychological phenotypes in the EMIF-AD Multimodal Biomarker Discovery dataset

This study performs GWAS on quantitative AD biomarkers and cognitive traits, identifying new loci associated with memory performance and cognitive decline.

Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer's disease-associated genes: DTNB and DLG2

This study identifies two novel Alzheimer's disease-associated genes, DTNB and DLG2, by analyzing rare variants in whole-genome sequencing data from AD family datasets.

Sleep duration and brain structure - phenotypic associations and genotypic covariance

This study examines the relationship between sleep duration and brain structure using MRI data, finding that 6.8 hours of sleep is associated with the most favorable brain outcomes, with genetic analyses suggesting homeostatic regulation of sleep duration.

Seven-CpG DNA Methylation Age determined by Single Nucleotide Primer Extension and Illumina's Infinium MethylationEPIC array provide highly comparable results

The paper compares DNA methylation age estimates from a 7-CpG clock using MS-SNuPE and the MethylationEPIC array, finding high correlation and developing an adjustment formula for conversion between methods.

Relationship between five Epigenetic Clocks, Telomere Length and Functional Capacity assessed in Older Adults: Cross-sectional and Longitudinal Analyses

This study examines the relationship between epigenetic clocks, telomere length, and functional aging in older adults using cross-sectional and longitudinal data, finding no significant associations.

Individual variations in Brain age relate to early life factors more than to longitudinal brain change

This study finds that adult brain age is more influenced by early life factors like birth weight and polygenic scores than by longitudinal brain decline.

TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels

The paper conducts GWAS on CSF Alzheimer's disease biomarkers, identifying genetic associations with NF-L, YKL-40, and Ng levels.

Self-Reported Sleep Relates to Microstructural Hippocampal Decline in β-Amyloid Positive Adults Beyond Genetic Risk

This study finds that worse self-reported sleep relates to faster hippocampal microstructural decline in β-amyloid positive adults, independent of genetic risk.

Whole-genome sequencing reveals new Alzheimer's disease-associated rare variants in loci related to synaptic function and neuronal development

Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women

This study identifies 15 genetic loci associated with muscle weakness in older adults through a large meta-analysis, revealing new pathways linked to aging and health outcomes.

Genome-wide association study of Alzheimer’s disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset

The paper conducts a genome-wide association study (GWAS) on Alzheimer’s disease CSF biomarkers in the EMIF-AD dataset, identifying novel genetic signals and confirming existing associations.

Genetic risk for Alzheimer`s disease predicts hippocampal volume through the lifespan

This study shows genetic risk for Alzheimer's disease affects hippocampal volume throughout life in a healthy population.