Michael E. Xie

Measuring neuronal input-output operations in vivo with random access projection microscopy

This paper introduces SLAP2, a high-speed microscope for measuring submicron synapses and dendritic voltage in behaving mice, revealing nonlinear input-output amplification in neurons.

GIAnT: a Glutamate Imaging Analysis Toolbox

GIAnT is a toolbox for analyzing glutamate imaging data that corrects motion, identifies active synapses, and improves signal quality.

Glutamate indicators with increased sensitivity and tailored deactivation rates

The paper develops two variants of a glutamate indicator with enhanced sensitivity and tailored deactivation rates for studying synaptic transmission in vivo.

High fidelity estimates of spikes and subthreshold waveforms from 1-photon voltage imaging in vivo

This paper introduces a method to accurately estimate spikes and subthreshold waveforms from 1-photon voltage imaging in vivo, even with noise.

All-optical electrophysiology reveals excitation, inhibition, and neuromodulation in cortical layer 1

All-optical electrophysiology in awake mice reveals inhibitory microcircuit function in barrel cortex Layer 1 by combining voltage recording with optogenetic manipulation.

All-optical electrophysiology reveals brain-state dependent changes in hippocampal subthreshold dynamics and excitability

The paper develops all-optical electrophysiology tools to record subthreshold dynamics and excitability in mouse hippocampus during behavior, revealing brain-state dependent changes in neuronal activity.