Anne E. Takesian

Layer 6 is a hub for cholinergic modulation in the mouse auditory cortex

The paper identifies layer 1 inhibitory neurons and layer 6 excitatory neurons as hubs mediating cholinergic modulation in the mouse auditory cortex through distinct receptor mechanisms.

Primary auditory thalamus relays directly to cortical layer 1 interneurons

The paper identifies a direct pathway from the primary auditory thalamus to cortical layer 1 interneurons in mice, showing these interneurons receive strong thalamic inputs comparable to excitatory neurons.

Reliable sensory processing of superficial cortical interneurons is modulated by behavioral state

The paper investigates how sensory inputs drive activity in superficial cortical interneurons and finds that their response reliability is modulated by behavioral state and neighboring interneuron activity.

An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes

The paper identifies enhancer-AAV tools for specific neuronal subtypes and validates them across species.

Neural signatures of auditory hypersensitivity following acoustic trauma

This study shows that acoustic trauma leads to non-homeostatic gain changes in auditory cortex neurons, contributing to hypersensitivity to sound.

Sensitive period-regulating genetic pathways and exposure to adversity shape risk for depression

The paper examines how genetic pathways regulating sensitive periods and socioeconomic disadvantage interact to influence depression risk using genome-wide data and developmental gene expression patterns.

All-optical electrophysiology reveals excitation, inhibition, and neuromodulation in cortical layer 1

All-optical electrophysiology in awake mice reveals inhibitory microcircuit function in barrel cortex Layer 1 by combining voltage recording with optogenetic manipulation.