Stem cell derived astrocytes with POLG mutations and mitochondrial dysfunction including abnormal NAD+ metabolism is toxic for neurons
Kristina Xiao Liang, Atefeh Kianian, Anbin Chen, Cecilie Katrin Kristiansen, Yu Hong, Jessica Furriol, Lena Elise Høyland, Mathias Ziegler, Torbjørn Kråkenes, Charalampos Tzoulis, Gareth J. Sullivan, Laurence Albert Bindoff
This study shows that POLG mutations in astrocytes cause mitochondrial dysfunction and neurotoxicity, leading to neuronal death through altered metabolism and reactive astrocyte behavior.
bioRxiv · Dec 20, 2020 · PreprintNeuroscience