Guido Sebastiani

Unconventional Small Molecule MNP-021 Protects Neuronal and Glial Function from Diabetes-Associated Glucotoxicity and Neuroinflammation

This paper tests the neuroprotective effects of MNP-021 against diabetes-induced glucotoxicity and neuroinflammation in neurons and glial cells, finding it restores glucose handling, mitochondrial function, and pro-resolving signaling.

5'tRNA-derived fragments modulate β-cell homeostasis and islet macrophage activation in type 2 diabetes

This study identifies 5'tRNA-derived fragments as mediators of β-cell dysfunction and islet macrophage activation in type 2 diabetes.

Small non-coding RNA profiling reveals inflammatory and mitochondrial related changes in aging β-cells and islet macrophages

This study profiles small non-coding RNAs in aging β-cells and islet macrophages, identifying age-related changes in miRNAs and tRFs linked to inflammation and mitochondrial function.

Comprehensive IsomiR sequencing profile of human pancreatic islets and EndoC-βH1 beta-cells

This study profiles isomiRs in human pancreatic islets and beta cells, finding they represent a significant fraction of miRNAs and are associated with beta cell function.