Niklas Schwarz

SynTEF1 restores the functional disease phenotype of SCA27B in an hiPSC-derived neuronal model

This study shows that SynTEF1 restores FGF14 expression and neuronal function in SCA27B patient-derived neurons.

Comprehensive Analysis of Human Dendritic Spine Morphology and Density: Exploring Diversity of Human Dendritic Spines

This study analyzes human dendritic spine morphology and density using a unique dataset and deep learning, revealing sex and tissue-specific differences and changes over time in culture.

Effective excitability captures network dynamics across development and phenotypes

The paper develops a dynamical system model to characterize in vitro neuronal network bursting dynamics across development and cell types, finding that effective excitability reliably captures these differences.

Morphotype-specific calcium signaling in human microglia

The paper analyzes Ca2+ signaling in human microglia and finds differences in signal properties across morphotypes.

Long-term human organotypic brain slice cultures: a detailed protocol to provide a comprehensive framework for single-neuron and neuronal network investigations

This paper provides a detailed protocol for long-term human organotypic brain slice cultures, enabling extended electrophysiological studies and viral transduction.

Modulating effects of FGF12 variants on NaV1.2 and NaV1.6 associated with Developmental and Epileptic Encephalopathy and Autism Spectrum Disorder

The paper identifies FGF12 variants linked to DEE and ASD and shows their functional effects on NaV1.2 and NaV1.6 sodium channels, revealing complex gain- and loss-of-function changes.

Human cerebrospinal fluid induce neuronal excitability changes in resected human neocortical and hippocampal brain slices

This study shows that human cerebrospinal fluid (hCSF) increases neuronal activity and network reconfiguration in human brain slices compared to artificial cerebrospinal fluid (aCSF).