Ivica Kostović

This study reconstructs the development of short association fibers in the human fetal brain using diffusion MRI and histology validation, revealing their maturation patterns and implications for neurodevelopmental disorders.

The paper uses NMF on MRI data to identify white matter maturation patterns in newborns, showing distinct microstructural and histological features.

This study examines microglial dynamics across the human lifespan using postmortem tissues and RNAseq data, revealing novel developmental patterns linked to neurodevelopmental milestones.

The paper shows that trisomy 21 cerebral organoids exhibit AD-like pathology, which can be suppressed by BACE2 trisomy and inhibited by BACE1 inhibitors, suggesting BACE2 as an AD-suppressor gene.