Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction
Lucas Charles Reineke, Ping Zhu, Udit Dalwadi, Sean W. Dooling, Yuwei Liu, I-Ching Wang, Sara K. Young, James T. Okoh, Santosh Kumar Kuncha, Hongyi Zhou, Akshara Kannan, Hyekyung Park, Nicolas A. DeBeaubien, Tristan Ian Croll, D. John Lee, , Mauro Costa‐Mattioli
This study investigates how a genetic variant disrupts proteostasis networks, leading to cognitive dysfunction, and identifies a viral protein that can reverse these deficits.
bioRxiv · Feb 28, 2025 · PreprintNeuroscience