Mauro Costa‐Mattioli

Peroxisome quality control is gated by a dynamic ATF6α-ABCD3 tether

This paper identifies ATF6α as a non-transcriptional regulator of peroxisome quality control through its interaction with ABCD3, and shows how this interaction can be modulated by Ceapin to influence cancer-related processes.

Allosteric Disordering of eIF2B Regulates the Integrated Stress Response

This study identifies an allosteric mechanism in eIF2B that regulates the Integrated Stress Response by showing how eIF2-P binding inhibits eIF2B activity through latch-helix dislocation.

Infant gut microbiomes contribute to metabolic states that impact brain function

The paper shows that infant gut microbiomes influence metabolic states that affect brain function, with interventions restoring normal behavior in mice.

IRE1 drives a homeostatic response to reduced protein influx into the endoplasmic reticulum

The paper identifies a third mode of IRE1 activation called TRES, triggered by reduced protein influx into the ER, leading to a distinct gene expression program to rebalance ER load.

Stereoselective methyl-swapping demonstrates target specificity of cognitive enhancer

The paper demonstrates that a modified ISRIB analog selectively targets a mutant eIF2B, improving synaptic plasticity and memory in mice, confirming its on-target mechanism.

Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction

This study investigates how a genetic variant disrupts proteostasis networks, leading to cognitive dysfunction, and identifies a viral protein that can reverse these deficits.

Mapping the ISR Landscape in Cognitive Disorders via single-cell multi-omics

The paper generates a single-cell ISR atlas in a mouse model of persistent ISR activation, identifying cell-type-specific ISR programs and their roles in cognitive decline.

A CRISPR toolbox for generating intersectional genetic mice for functional, molecular, and anatomical circuit mapping

The paper introduces a CRISPR toolkit for generating intersectional genetic mice to study cellular circuits, demonstrating its use in neuronal and ovarian populations.

Excessive ERK-dependent synaptic clustering with enhanced motor learning in the MECP2 duplication syndrome mouse model of autism

The paper shows that in MECP2 duplication syndrome mice, excessive ERK-dependent synaptic clustering enhances motor learning, suggesting a mechanism for abnormal learning in autism.