Author

Lucas Charles Reineke

Altos LabsORCID 0000-0002-8983-7696Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Mauro Costa‐MattioliiD· 3 shared Peter WalteriD· 3 shared Adam S. FrostiD· 2 shared Christopher P. ArthuriD· 2 shared D. John LeeiD· 2 shared Sean W. DoolingiD· 2 shared Tristan Ian CrolliD· 2 shared Udit DalwadiiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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3 shared papersNeuroscience

Mauro Costa‐MattioliORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Allosteric Disordering of eIF2B Regulates the Integrated Stress Response

Udit Dalwadi, Advait Subramanian, Aniliese Deal, Julia E. Conrad, Tamara Nadjsombati, Meera Venkatesh, Morgane Boone, Pascal F. Egea, Ling-jie He, Nimit Jain, D. John Lee, Yuwei Liu, Lucas Charles Reineke, Kazuki Saito, Nathaniel Talledge, , Adam S. Frost

This study identifies an allosteric mechanism in eIF2B that regulates the Integrated Stress Response by showing how eIF2-P binding inhibits eIF2B activity through latch-helix dislocation.

Nature Chemical Biology · Jun 29, 2026Peer-reviewedBiochemistry

Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction

Lucas Charles Reineke, Ping Zhu, Udit Dalwadi, Sean W. Dooling, Yuwei Liu, I-Ching Wang, Sara K. Young, James T. Okoh, Santosh Kumar Kuncha, Hongyi Zhou, Akshara Kannan, Hyekyung Park, Nicolas A. DeBeaubien, Tristan Ian Croll, D. John Lee, , Mauro Costa‐Mattioli

This study investigates how a genetic variant disrupts proteostasis networks, leading to cognitive dysfunction, and identifies a viral protein that can reverse these deficits.

bioRxiv · Feb 28, 2025 · PreprintNeuroscience

Mapping the ISR Landscape in Cognitive Disorders via single-cell multi-omics

Kristof A. Torkenczy, Lucas Charles Reineke, Sean W. Dooling, Benjamin Henderson, Daniel N. Itzhak, Benjamin A. Yang, Dongze He, R Myers, Peter Walter, Stefka Tyanova, Mauro Costa‐Mattioli

The paper generates a single-cell ISR atlas in a mouse model of persistent ISR activation, identifying cell-type-specific ISR programs and their roles in cognitive decline.

bioRxiv · Feb 28, 2025 · PreprintNeuroscience