Author

Nicolas A. DeBeaubien

Altos LabsORCID 0000-0002-5253-2186Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Mauro Costa‐MattioliiD· 2 shared Peter WalteriD· 2 shared Tristan Ian CrolliD· 2 shared Adam S. FrostiD· 1 shared Advait SubramanianiD· 1 shared Akshara KannaniD· 1 shared Benjamin Yang· 1 shared Christopher P. ArthuriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCell Biology

Mauro Costa‐MattioliORCID

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2 papers

Recent·Most cited

IRE1 drives a homeostatic response to reduced protein influx into the endoplasmic reticulum

Francesca Zappa, Advait Subramanian, Benjamin Yang, Julia E. Conrad, Tsan‐Wen Lu, Jing Wang, Nicolas A. DeBeaubien, Rose Yan, Renato Minopoli, Tristan Ian Croll, Stefka Tyanova, Mauro Costa‐Mattioli, Peter Walter, Diego Acosta‐Alvear

The paper identifies a third mode of IRE1 activation called TRES, triggered by reduced protein influx into the ER, leading to a distinct gene expression program to rebalance ER load.

bioRxiv · Mar 9, 2026 · PreprintCell Biology

Harnessing the Evolution of Proteostasis Networks to Reverse Cognitive Dysfunction

Lucas Charles Reineke, Ping Zhu, Udit Dalwadi, Sean W. Dooling, Yuwei Liu, I-Ching Wang, Sara K. Young, James T. Okoh, Santosh Kumar Kuncha, Hongyi Zhou, Akshara Kannan, Hyekyung Park, Nicolas A. DeBeaubien, Tristan Ian Croll, D. John Lee, , Mauro Costa‐Mattioli

This study investigates how a genetic variant disrupts proteostasis networks, leading to cognitive dysfunction, and identifies a viral protein that can reverse these deficits.

bioRxiv · Feb 28, 2025 · PreprintNeuroscience