Henrik Alle

This study compares the effects of AMPA receptor inhibitors on seizure-like events in murine and human brain slices, finding species-specific differences in drug efficacy.

The paper investigates electrical signaling between mid-capillary pericytes and endothelial cells in the neurovascular unit, showing syncytial coupling and its role in transmitting seizure-associated signals without relying on VGCCs.

The paper characterizes neuronal and synaptic diversity in human layer 2-3 pyramidal neurons across individuals, finding that neuronal physiology varies with laminar depth while synaptic properties are consistent.

This study shows NASPM inhibits NMDA receptors rather than CP-AMPARs in human brain tissue, challenging its use as a specific CP-AMPAR inhibitor and questioning its therapeutic potential.

The paper demonstrates that gamma-oscillation plasticity in the hippocampus is mediated by parvalbumin interneurons through specific metabotropic signaling pathways.

This study examines synaptic dynamics in the subthalamic nucleus (STN) and substantia nigra pars reticulata (SNr) during high frequency stimulation, finding sustained inhibitory effects in STN compared to SNr.

This paper introduces a high-throughput in-vitro multipatch setup for analyzing microcircuits in human brain tissue, enabling the study of synaptic connections across multiple neurons.