Author

Tse-Luen Wee

Cold Spring Harbor LaboratoryORCID 0000-0002-4141-3157Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Adrian M. GomeziD· 1 shared Ava SanniD· 1 shared Chao ZhangiD· 1 shared Corina AmoriD· 1 shared Evdokia MichalopoulouiD· 1 shared Jeremy C. BornigeriD· 1 shared Joseph Gewolb· 1 shared Justin R. CrossiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Adrian M. GomezORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Macropinocytosis enables metabolic recycling of extracellular DNA in cancer cells

Wen‐Hsuan Yang, Olivia T. Stamatatos, Evdokia Michalopoulou, Ava Sann, Paolo Cifani, Linda Van Aelst, Justin R. Cross, Tse-Luen Wee, Michael J. Lukey

This study shows cancer cells use macropinocytosis to take up extracellular DNA, which is then degraded to supply nucleotides, and highlights SLC29A3 as a key mediator of this process.

bioRxiv · Oct 22, 2025 · PreprintCancer Biology

A brain-body feedback loop driving HPA-axis dysfunction in breast cancer

Adrian M. Gomez, Yue Wu, Chao Zhang, Leah Boyd, Tse-Luen Wee, Joseph Gewolb, Corina Amor, Lucas Cheadle, Jeremy C. Borniger

This study shows that breast cancer disrupts hypothalamic GC rhythms by altering PVNCRH neuron activity, and that targeting these neurons can reduce tumor progression.

bioRxiv · Sep 13, 2024 · PreprintNeuroscience