Cancer BiologybioRxivPreprint
Macropinocytosis enables metabolic recycling of extracellular DNA in cancer cells
Wen‐Hsuan Yang, Olivia T. Stamatatos, Evdokia Michalopoulou…·Michael J. Lukey
This study shows cancer cells use macropinocytosis to take up extracellular DNA, which is then degraded to supply nucleotides, and highlights SLC29A3 as a key mediator of this process.
DOI 10.1101/2025.10.22.684010