Claudia Ctortecka

This study establishes quality control standards for single-cell proteomics through inter-laboratory benchmarking, identifying software and technical factors affecting data reliability.

This paper develops a mass spectrometry-based method to profile single-cell histone post-translational modifications, demonstrating its ability to detect treatment responses and chromatin heterogeneity.

This study identifies rare tumor-reactive T cells and conserved antigen repertoires in multiple myeloma and acute myeloid leukemia, developing a TCR fitness model to predict immunotherapy response.

This paper presents an optimized workflow for high-throughput proteomic and phosphoproteomic analysis of FFPE tissues, achieving deep coverage and quantitative robustness comparable to TMT-based methods.

This study presents an automated single-cell proteomics workflow that identifies over 4,000 proteins per cell and detects key regulatory proteins in LPS-perturbed THP-1 cells.

This paper establishes self-organizing cardioids from human pluripotent stem cells that form chamber-like structures and identifies signaling pathways governing their development.