Sam Guoping Gu

This study shows hypoxia promotes metastasis in pancreatic cancer by suppressing Kdm8, leading to epigenetic and transcriptomic changes, increased chromosomal instability, and metastatic disease.

This study identifies SET-21 as a novel H3K23 histone methyltransferase that synergizes with SET-32 to promote transgenerational epigenetic inheritance via nuclear RNAi in C. elegans.

The paper shows that siRNA suppression in C. elegans germline depends on target genes, distinguishing self from non-self siRNAs.

The paper identifies SPE-51, a secreted protein in C. elegans, essential for sperm-egg fusion, and shows it localizes to the sperm surface.

This study identifies SET-32 as the enzyme depositing H3K23me3, a heritable histone modification induced by nuclear RNAi in C. elegans.

This study identifies SET-32 as essential for the transgenerational establishment of nuclear RNAi-mediated silencing in C. elegans, showing it is dispensable for maintenance once silencing is established.

The paper investigates the spatial and temporal dynamics of nuclear RNAi-targeted RNA transcripts in C. elegans, revealing their nuclear localization and developmental coupling with germline cell cycles.

This study identifies spe-43 as a gene required for spermiogenesis in C. elegans, showing that it is necessary for sperm activation in hermaphrodites but not in males.