Matteo Pecoraro

Droplet single-cell CRISPR screens identify regulators of T cell-mediated target-cell killing

The paper uses droplet single-cell CRISPR screening to identify regulators of T cell-mediated target-cell killing and finds that mTORC1 modulation enhances cytotoxic activity.

Circulating extracellular vesicles drive microglial senescence and neurodegeneration in Parkinson`s disease

This study shows that circulating extracellular vesicles from Parkinson's disease patients induce microglial senescence and neurodegeneration by promoting inflammation and neuronal damage.

Structure of ATTRv-F64S fibrils isolated from skin tissue of a living patient

The paper reports the first cryo-EM structure of ATTRv-F64S fibrils from a living patient's skin tissue, validating skin biopsy as a non-invasive diagnostic tool.

Targeting FOXA1 and FOXA2 Disrupts the Lineage-Specific Oncogenic Output Program in Prostate Cancer

This study shows that disrupting FOXA1 and FOXA2 disrupts oncogenic programs in both AR-positive and AR-negative prostate cancers.

TRIM24 Degradation Counteracts Adaptation to Androgen Receptor Inhibition in Prostate Cancer

This study identifies TRIM24 as a target for preventing prostate cancer progression by degrading it to counteract AR inhibition adaptation and tumor relapse.

A proteomic map of B cell activation and its shaping by mTORC1, MYC and iron

This study maps the proteomic changes in B cells during activation and shows how mTORC1, MYC, and iron regulate protein production and growth.

High-throughput proteome profiling with low variation in a multi-center study using dia-PASEF

The paper benchmarks dia-PASEF with timsTOF HT for high-throughput proteome analysis in a multi-center study, showing consistent protein and peptide identification across laboratories.